Transplantation of stem cells, including mesenchymal stromal cells (MSCs), improves the recovery of cardiac function after myocardial infarction (MI) in experimental studies using animal models and in patients.However, the improvement of cardiac function following MSC transplantation remains suboptimal in both preclinical and clinical studies.Under
Background Mesenchymal stem cell-derived extracellular vesicles (EVs) appear to be a very exciting treatment option for heart disease.Here, we used a swine model of chronic myocardial ischemia to evaluate the efficacy of a less-invasive method of injection of EVs via a peripheral intravenous route.Methods Sixteen Yorkshire swine underwent placement
A series of N-acyl derivatives of anabasine and cytisine CITICOLINE were prepared, to discover novel, natural product-based medicinal agents.All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity.The most pronounced antibacterial activity was shown by the compounds with isoxazole fragments, while the a
Policisne de Boecia, the last printed romance of chivalry, proposes a variety of richly dressed Wash-in Waterproofer marginal characters.The pineos, dwarves and giants are dressed mainly in three types of materials: cloth, skin and animal bones.The relationship between textiles and the narrative function of Sterilization Packaging the wearer is ana